Selecta Lab’s cancer genomics testing analyzes mutations in a patient’s DNA known to be associated with an increased risk of hereditary cancer. Selecta Labs provides a comprehensive report indicating a patient’s potential susceptibility to various hereditary cancers. This testing uses the latest next generation sequencing technology to analyze patient samples in a rapid and accurate fashion.
This information helps guide a clinician’s route of personalized therapy dependent on the specific genomic mutation and associated cancer. Currently, Selecta Labs offers the analysis of thirtyseven (37) genes covering eighteen (18) different cancers as shown below:
**Click on the Gene to learn more about it**
| Gene(s) | Associated Cancer(s)/Tumor(s) |
| APC | Colorectal, central nervous system, thyroid, liver, duodenal, pancreatic |
| ATM | Breast, pancreatic |
| NBN | Breast, prostate, possibly ovarian |
| BRCA1, BRCA2 | Breast, ovarian, prostate, pancreatic, male breast |
| BRIP1, RAD51C, RAD51D |
Breast, ovarian |
| BMPR1A, SMAD4 | Stomach, colorectal, pancreatic |
| CDH1 | Breast, colorectal, gastric |
| CDK4 | Melanoma |
| CDKN2A | Melanoma, pancreatic |
| CHEK2 | Breast, colorectal |
| FH | Kidney, leiomyomas |
| FLCN | Kidney |
| MAX | Pheochromocytoma |
| MLH1, MSH2, MSH6, PMS2, EPCAM |
Ovarian, colorectal, uterine, stomach, small bowel, hepatobiliary, brain, pancreatic, sebaceous, urinary tract |
| MUTYH | Breast, colorectal |
| NF1 | Optic glioma, gastrointestinal stromal tumor, paraganglioma/pheochromocytoma, neurofibromas, breast, Central nervous system |
| PALB2 | Breast, pancreatic |
| PTEN | Breast, uterine, thyroid, colorectal, kidney |
| RET | Thyroid (medullary), Pheochromocytoma |
| SDHAF2, SDHB, SDHC, SDHD |
Kidney, paraganglioma/pheochromocytoma, gastrointestinal stromal tumor |
| TSC1, TSC2 | Kidney, cardiac rhabdomyomas, central nervous system |
| STK11 | Colorectal, small bowel, pancreatic, breast, ovarian |
| TMEM127 | Paraganglioma/pheochromocytoma |
| TP53 | Brain, leukemia, breast, sarcoma, adrenocortical, gastrointestinal, genitourinary |
| VHL | Kidney, pheochromocytoma, central nervous system |